HUBUNGAN ANTARA PENGETAHUAN ODAPUS DAN KEPATUHAN MINUM OBAT PADA ODAPUS MENGGUNAKAN METODE MMAS DAN LKQ DI MAGELANG
DOI:
https://doi.org/10.59737/jpi.v13i1.53Abstrak
Latar Belakang: Lupus Eritematosus Sistemik (LES) merupakan penyakit autoimun kronik dengan manifestasi beragam yang kompleks yang membutuhkan penatalaksanaan secara individual. Banyak faktor yang mempengaruhi keberhasilan penatalaksanaan Lupus, dimana kepatuhan minum obat adalah salah satunya. Terkait hal tersebut, ternyata ada banyak hal yang mempengaruhi tingkat kepatuhan. Penelitian ini merupakan langkah awal intervensi penatalaksanaan komprehensif bagi Odapus, khususnya dalam lingkup lokal di Magelang.Tujuan: Tujuan umum penelitian ini adalah untuk mengetahui hubungan antara pengetahuan Odapus dan kepatuhan minum obat pada Odapus menggunakan metode MMAS dan LKQ di Magelang. Sementara tujuan khusus penelitian antara lain untuk mengetahui distribusi frekuensi, tingkat kepatuhan minum obat, dan tingkat pengetahuan Odapus di Magelang.Metode: Jenis penelitian yang dilakukan adalah penelitian analitik korelasi dengan pendekatan cross sectional.Populasi penelitian adalah seluruh Odapus di Magelang sebanyak 40 orang. Sampel sebanyak 40 orang dengan teknik total sampling. Pengambilan data menggunakan lembar kuesioner. Teknik analisis data menggunakan uji statistik Kendall Tau.Hasil: Distribusi frekuensi kepatuhan minum obat pada Odapus sebagian besar dengan kategori rendah sebanyak 28 responden (70.00%), sementara distribusi frekuensi pengetahuan pada Odapus sebagian besar dengan kategori baik sebanyak 24 responden (60.00%). Simpulan: Tidak ada hubungan signifikan antara tingkat pengetahuan dengan kepatuhan minum obat pada Odapus (p-value 0,134 > α 0,05). Mayoritas Odapus di Magelang berjenis kelamin wanita (97.50%), berusia 18-31 tahun (65.00%), mengenyam pendidikan SMA atau sederajat (52.50%) dan bekerja sebagai ibu rumah tangga (32.50%). Kebanyakan Odapus telah menyintas LES selama 3-5 tahun (40.00%), kontrol kembali ke poliklinik setiap bulan (90.00%), dan mengkonsumsi kombinasi lebih dari 3 jenis obat per hari. Jenis obat yang paling banyak dikonsumsi adalah kombinasi kortikosteroid dan DMARDs atau imunosupresan (50.00%).
Kata kunci: Lupus, Odapus, pengetahuan, kepatuhan minum obat
Referensi
Ahn, CS., Culp, L. Huang, WW., et al. 2017. Adherence in dermatology. J Dermatolog Treat. 2017; 28(2): 94-104.
Alplalhao, M., Antunes, J., Gouveia, A., et al. A randomized controlled clinical trial to assess the impact of motivational phone calls on therapeutic adherence in patients suffering from psoriasis. Dermatol Ther. 2018; 31: e12667.
Almoallim, H., Bukhari, E., Amasaib, W., et al. 2012. How to Avoid Delay in SLE Diagnosis and Management, Systemic Lupus Erythematosus, Almoallim, H. (Ed)., InTechOpen.
American College of Rheumatology. Guidelines for referral and management of systemic lupus erythematosus on adults. American College of Rheumatology Ad Hoc Committee on Systemic Lupus Erythematosus Guidelines. Arthritis Rheum 1999; 42(9): 1785-96.
Amissah-Arthur, MB. dan Gordon, C. Contemporary treatment of systemic lupuserythematosus: an update for clinicians. Ther Adv Chronic Dis. 2010; 1(4): 163-75.
Aringer, M., Costenbader, K., Daikh, D., et al. 2019 European League Against Rheumatism/American College of Rheumatology Classification Criteria for Systemic Lupus Erythematosus. Arthritis & Rheumatology. 2019; 0(0): 1-13.
Azwar, S. 2012.Penyusunan Skala Psikologi Edisi 2. Yogyakarta: Pustaka Pelajar.
Bacen, EA., Chesney, MA., dan Criswell, LA. Prevalence of mood and anxiety disorder in women with systemic lupus erythematosus. Arthritis Rheum. 2009; 61(6): 822-29.
Barber, N., Safdar, A., dan Franklin, BD. Can human error theory explain non-adherence?.Pharm World Sci. 2005; 27: 300-04.
Benedetti, F. Placebo Effects: Understanding the Mechanism in Health and Disease, 2nd edition. 2015. Oxford: Oxford University Press.
Bertsias, GK., Tektonidou, M., Amoura, Z., et al. Joint European League Against Rheumatism and European Renal Association-European Dialysis and Transplant Association (EULAR/ERA-EDTA) recommendations for the management of adult and paediatric lupus nephritis. Ann Rheum Dis. 2012; 71: 1771-82.
Brown, KK., Rehmus, WE., dan Kimball, AB. Determining the relative importance
of patient motivation for nonadherence to topical corticosteroid therapy in psoriasis. J Am Acad Dermatol. 2006; 55(4): 607-13.
Brunner & Suddarth. Buku Ajar Keperawatan Medikal Bedah, alih bahasa: Waluyo
Agung, Yasmin Asih, Juli, Kuncara, I Made Karyasa. 2002. Jakarta: EGC.
Carroll, CL., Feldman, SR., Camacho, FT., et al. Adherence to topical therapy decreases during the course of an 8-week psoriasis clinical trial: commonly used methods of measuring adherence to topical therapy overestimate actual use. J Am Acad Dermatol. 2004; 51: 212-16.
Claxton, AJ., Cramer, J., dan Pierce, C. A Systematic Review of the Association Between Dose Regimens and Medication Compliance. Clinical Therapeutics. 2001; 23(8): 1296-1310.
Cork, MJ. Britten, J., Butler, I., et al.Comparison of parent knowledge, therapy utilization and severity of atopic eczema before and after explanation and demonstration of topical therapies by a specialist dermatology nurse. British Journal Dermatology. 2003;149: 582-89.
Cramer, JA.A Systematic Review of Adherence With Medication for Diabetes. Diabetes Care. 2004;27(5): 1218-24.
David, W. dan Djamaris, ARA. 2018. Metode Statistik Untuk Ilmu dan Teknologi Pangan. Jakarta: Penerbitan Universitas Bakrie.
De Achaval, S. dan Suarez-Almazor, ME. Treatment adherence to disease-modifying antirheumatic drugs in patients with rheumatoid arthritis and systemic lupus erythematosus. Int J Clin Rheumatol. 2010; 5(3): 313-26.
Denniston, AK., Kyte, D., Calvert, M., et al. An introduction to patient-reported outcome measures in ophthalmic research. Eye. 2014; 28(6): 1-9.
Desmisalgli, AE. Dukungan Sosial Keluarga dan Spirit Menjadi Penderita Lupus Eritematosus Sistemik. DCP. 2102; 1(1): 15-20.
Dewi, ES., Soemardini, dan Rini, IS. Efektivitas Terapi Kompres Dingin dalam Menurunkan Stres Orang dengan Lupus (Odapus) Dewasa Muda di Perhimpunan Masyarakat Peduli Lupus Parahita Malang. 2016; 3(2): 65-75.
Dwajani, S., Prabhu, MR., Ranjana, G., et al. Importance of medication adherence and factors affecting it. IP International Journal of Comprehensive and Advanced Pharmacology. 2018; 3(2): 69-77.
Eicher, L., Knop, M., Aszodi, N. A systematic review of factors influencing treatment adherence in chronic inflammatory skin disease– strategies for optimizing treatment outcome. JEADV. 2019; 33: 2253-63.
Evers, AW. Using the placebo effects: how expectations and learned immune function can optimize dermatological treatments. Exp Dermatol. 2017; 26: 18-21.
Fatmawati, A. Regulasi diri pada penyakit kronis – systemic lupus erythematosus: kajian literatur. Jurnal Keperawatan Indonesia. 2018; 21(1): 43-50.
Feinstein, AR. On white-coat effects and the electronic monitoring of compliance. Arch Intern Med. 1990; 150: 1377-78.
Figueiredo-Braga, M., Cornaby, C., Bernardes, M., et al. Correlation between physical markers and psychiatric health in Portuguese systemic lupus erythematosus cohort: The role of suffering in chronic autoimmune disease. PLoS ONE. 2018; 13(4): 1-16.
Forum, European Patients. 2015. Adherence and Concordance EPF Position Paper. Brussels: European Patients Forum.
Fanourakis, A., Kostopolou, M., Alunno, A. 2019 update of the EULAR recommendations for the management of systemic lupus erythematosus. Ann Rheum Dis. 2019; 78: 736-45.
Farkhati, MY., Hapsara S., dan Satria, CD. Antibodi Anti-dsDNA Sebagai Faktor Prognosis Mortalitas pada Lupus Eritematosus Sistemik. Sari Pediatri. 2012; 14: 2-8.
Farzaneh-Far, A., Roman, MJ., Lockshin, MD., et al. Relationship of Antiphospholipid Antibodies to Cardiovascular Manifestations of Systemic Lupus Erythematosus. Arthritis & Rheumatism. 2006; 54(12): 3918-25.
Fauzi, YS. 2019. Hubungan Antara Efikasi Diri Terhadap Kepatuhan Minum Obat Anti Tuberkulosis (OAT) di Puskesmas Rawat Inap Panjang. Skripsi. Fakultas Kedokteran, Universitas Lampung Bandar Lampung.
Feldman, SR., Camacho, FT., Krejci-Manwaring, J., et al. Adherence to topical therapy increases around the time of office visits. J Am Acad Dermatol. 2007; 57: 81-3.
Feldman, SR., Vrijens, B., Gieler, U., et al. Treatment adherence intervention studies in dermatology and guidance on how to support adherence. Am J Clin Dermatol. 2017; 18: 253-71.
Geargianaki, I. dan Bortoluzzi, A. Update on the epidemiology, risk factors, and disease outcomes of systemic lupus erythematosus. Best Practice & Research Clinical Rheumatology. 2018; 3: 1-18.
Giffords, ED. Understanding and Managing Systemic Lupus Erythematosus (SLE). Soc Work Health Care. 2003. 37(4): 57-72.
Ghozali, I. Aplikasi Analisis Multvariate dengan Program IBM SPSS 19 Edisi 5. Semarang: Badan Penerbit Universitas Diponegoro.
Gordon, C., Amissah-Arthur, MB., Gayed, M., et al. The British Society for Rheumatology guideline for the management of systemic lupus erythematosus in adults. Rheumatology. 2018; 57: 1-45.
Gupta, G., Mallefet, P., Kress, DW., et al.Adherence to topical dermatological therapy: lessons from oral drug treatment. Br J Dermatol. 2009; 161: 221-27.
Harrison, MJ., Ravdin, LD., dan Lockshin, MD. Relationship Between Serum NR2a Antibodies and Cognitive Dysfunction in Systemic Lupus Erythematosus. Arthritis & Rheumatism. 2006; 54(8): 2515-22.
Hashmi, SK., Afridi, MB., Abbas, K., et al. Factors Associated with Adherence to Anti-Hypertensive Treatment in Pakistan. PLoS ONE. 2007; 2(3): 1-8.
Hochberg, MC., Gravallese, EM., Silman, AJ., et al. (Ed.). Rheumatology Seventh Edition. 2019. Philadelphia: Elsevier
Hochberg, MC. Updating the American College of Rheumatology revised criteria for the classification of systemic lupus erythematosus. Arthritis Rheum. 1997; 40(9): 1725-34.
Hodari, KT., Nanton, JR., Carroll, CL., et al. Adherence in dermatology: a review of the last 20 years. J Dermatolog. Treat. 2006; 17: 136-142.
Holmes, EAF., Hughes, DA., dan Morrison, VL. Predicting Adherence to Medications Using Health Psychology Theories: A Systematic Review of 20 Years of Empirical Research. Value in Health. 2014; 17: 863-76.
Ho, RC., Husain, SF., dan Ho, CS. Cognitive dysfungction in patients with systemic lupus erythematosus: The challenge in diagnosis and management. Rheumatology Practice and Research. 2018; 3: 1-12.
Horne, R. Compliance, Adherence and Concordance: Implications for asthma treatment. Chest Journal. 2006; 130: 65-72.
Horne, R., Weinman, J., Barber, N., et al. Concordance, Adherence, & Compliance in Medicine Taking.Centre for Health Care Research. University of Brighton. 2005. Brighton: Falmer.
Inderjeeth, CA., Habib. P., Sharma, C., et al. Systemic Lupus Erythematosus: Reducing life-threatening progression. Medicine Today. 2018; 19(9): 31-42.
Indonesia, Perhimpunan Reumatologi. Rekomendasi Perhimpunan Reumatologi Indonesia Diagnosis dan Pengelolaan Lupus Eritematosus Sistemik. 2011. Jakarta: Perhimpunan Reumatologi Indonesia.
Irawati, S., Prayitno, A., Angel, et al. Studi Pendahuluan Profil Penggunaan Obat dan Kepatuhan terhadap Pengobatan pada Pasien Lupus di Komunitas.Jurnal Sains Farmasi & Klinis. 2016; 2(1): 78-83.
Jaglarz, K, Tomaszewski, KA., Kamzol, W., et al. Creating and field-testing the questionnaire for the assessment of knowledge about cervical cancer and its prevention among schoolgirls and female students. Journal of Gynecologic Oncology. 2014; 25(2): 81-89.
Jackson, JM. dan Pelle, M. Topical rosacea therapy: the importance of vehicles for
efficacy, tolerability and compliance. J Drugs Dermatol. 2011; 10: 627-33.
Johnson, C., Aaronson, N., Blazeby, JM., et al. Guidelines for Developing Questionnaire Modules Quality of Life Group. EORTC Quality of Life Group.
Kalim, H., Handono, K, Hasanah D. Hubungan Kadar Vitamin D dengan Jumlah Sel T Regulator pada Pasien Lupus Erithematosus Sistemik. Jurnal Penelitian Fundamental Universitas Brawijaya. 2011;5: 114-7.
Kubler-Ross, E. dan Kessler, D. On Grief and Grieving: Finding the Meaning of Grief Through the Five Stages of Loss. 2014. New York: Scribner.
Eenam HA., Poon, AW., de los Angeles, C., et al. Psychiatric complications of treatment with corticosteroids: Review with case report. Psychiatry and Clinical Neurosciences. 2011;65: 549-60.
Kimura, D., Shah, S., Briceno-Medina, M., et al. Management of massive diffuse alveolar hemorrhage in child with systemic lupus erythematosus. J Intensive Care. 2015;3: 10.
Krejci-Manwaring, J., Tusa, MG., Carroll, C., et al. Stealth monitoring of adherence to topical medication: adherence is very poor in children with atopic dermatitis. J Am Acad Dermatol. 2007; 56: 211-16.
Kumar, V., Abbas, AK., dan Aster, JC. Robbins Basic Pathology Tenth Edition.2018. Philadelphia: Elsevier.
Kushnir, NM. 2014. Autoimmune Disorders: Making Sense of Nonspesific Symptoms. Medscape, 10 July 2014. [Online].
Available at:
https://reference.medscape.com/features/slideshow/autodisorders.
[Accessed 29 October 2019]
Kolios, AGA., Hueber, AJ., Michetti, P., et al. ALIGNed on adherence: subanalysis of adherence in immune-mediated inflammatory diseases in the DACH region of the global ALIGN study. JEADV. 2019;33: 234-41.
Lailatushifah, SNF. 2010. Kepatuhan Pasien yang Menderita Penyakit Kronis Dalam Mengkonsumsi Obat Harian. Insight, hal. 1-9. Fakultas Psikologi Universitas Mercu Buana Yogyakarta.
Lawson, EF., Trupin, L., Yelin, EH., et al. Reasons of Failure to Receive Pneumococcal and Influenza Vaccinations Among Immunosuppressed Patients with Systemic Lupus Erythematosus. Semin Arthritis Rheum. 2015; 44(6): 666-71.
Longo, DL., Kasper, DL., Jameson, JL., et al. (Ed.). 2012. Harrison’s Principles of Internal Medicine Eighteenth Edition. New York: The McGraw-Hill Companies, Inc.
Malta, M., Petersen, LM., Clair, S., et al.Compliance to antiretroviral therapy: a qualitative study with physicians from Rio de Janeiro, Brazil. Cad. Saude Publica, Rio de Janeiro. 2016; 123(6):1386-94.
Marmor, MF., Kellner, U., Lai, TYY., et al.Recommendations on screening for chloroquine and hydroxychloroquine retinopathy (2016 revision). Ophtamology. 2005; 21(5):1424-32.
Melles, RB. dan Marmor, MF. The risk of toxic retinopathy in patients on long-term hydroxychloroquine therapy. JAMA Ophtalmol. 2014; 132(12):1453-60.
Moharamzad, Y., Saadat, H., Shahraki, BN., et al. Validation of the Persian Version of the 8-Item Morisky Medication Adherence Scale (MMAS-8) in Iranian Hypertensive Patients. Global Journal of Health Science. 2015; 7(4): 173-83.
Morgan, M. dan Horne, R. Explaining patient’s behavior. Report for the national Co-ordinator Centre for NHS Service Delivery and Organization R & D (NCCSDO). Centre for Health Care Research. University of Brighton. 2005. Brighton: Falmer.
Morisky, DE., Ang, A., Wood, MK, et al. Predictive Validity of a Medication Adherence Measure in an Outpatient Setting. The Journal of Clinical Hypertension. 2008; 10(5): 348-54.
Morisky, DE. dan Muntner, P. A New Medication Adherence Scale Versus Pharmacy Fill Rates in Senior with Hypertension. American Journal of Managed Care. 2009; 15(1): 59-66.
National Council on Patient Information and Education. Enhancing Prescription Medicine Adherence: A National Action Plan. 2007. Rockville: National Council on Patient Information and Education.
Notoatmodjo, S. Metodologi Penelitian Kesehatan.2012. Jakarta: PT. Rineka Cipta.
Novianti, S. 2018. Faktor-Faktor Yang Mempengaruhi Kepatuhan Minum Obat Kortikosteroid Pada Pasien Sistemik Lupus Eritematosus di RS Kramat 128 Tahun 2018. Skripsi. Fakultas Ilmu Keperawatan, Universitas Muhammadiyah Jakarta.
Nuryadi, Astuti, TD., Utami, ES., et al. 2017. Dasar-Dasar Statistik Penelitian. Yogyakarta: Sibuku Media.
Osterberg, L. dan Blaschke, T..Adherence to medication. New England Journal of Medicine. 2005; 353(5): 487-97.
Picardi, A., Abeni, D., Melchi, CF., et al. Psychiatric morbidity in dermatological outpatients: An issue to be recognized. Br J Dermatol. 2000; 14: 920-21.
Pratita, ND. Hubungan Dukungan Pasangan dan Health Locus of Control dengan Kepatuhan Dalam Menjalani Proses Pengobatan Pada Penerita Diabetes Mellitus Tipe-2. Calytra: Jurnal Ilmiah Mahasiswa Universitas Surabaya. 2012; 1(1): 1-24.
Rahmadani. 2017. Pengaruh Tingkat Pengetahuan Terhadap Kualitas Hidup Dengan Kepatuhan Penggunaan Obat Sebagai Variabel Antara Pada Pasien Rheumatoid Arthritis di Depo Farmasi Rawat Jalan RSUD Dr. Moewardi Surakarta. Tesis. Fakultas Farmasi, Universitas Setia Budi Surakarta.
Rees, F., Doherty, M., Grainge, MJ., et al. The worldwide incidence and prevalence of systemic lupus erythematosus: a systematic review of epidemiological studies. Rheumatology. 2017; 56: 1945-61.
Reeve, BB., Wyrwich, KW., Wu, AW., et al. ISOQOL recommends minimum standards for patient-reported outcome measures used in patient-centered outcomes and comparative effectiveness research. Quality of Life Research. 2013; 22: 1889-1905.
Renzi, C., Picardi, A., Abeni, D., et al. Association of dissatisfaction with care and
psychiatric morbidity with poor treatment compliance. Arch Dermatol. 2002; 138 (3): 337-42.
RI, Depkes. Pedoman Nasional Penanggulangan Tuberkulosis. 2000. Jakarta: Departemen Kesehatan RI.
RI, Depkes. Pedoman Nasional Penanggulangan Tuberkulosis. 2006. Jakarta: Departemen Kesehatan RI.
RI, Kementerian Kesehatan. InfoDATIN Situasi Lupus di Indonesia. 2017. Jakarta: Kementerian Kesehatan RI.
Roussou, E., Iacovou, C., Weerakoon, A., et al. Stress as a trigger of disease flares in SLE. Rheumatol Int. 2013; 33(5): 1367-70.
Ruiz-Irastorza, G., Ramos-Casals, M., Brito-Zeron, P., et al. Clinical efficacy and side effects of antimalarials in systemic lupus erythematous: A systematic review. Ann Rheum Dis. 2010; 69(1): 20-8.
Sarwono, J. 2006. Buku Metodologi Penelitian Kuantitatif dan Kualitatif. Yogyakarta: Graha Ilmu.
Sawah, SA. Zhang, X., Zhu, B., et al. Effect of corticosteroid use by dose on the risk of developing organ damage over time in systemic lupus erythematosus–the Hopkins Lupus Cohort. Lupus Science & Medicine. 2015; 2: 1-9.
Setiabudiawan, B. dan Ghrahani. Indonesian Epidemiologic Data of PaediatricSystemic Lupus Erythematosus. Lupus. 2017; 4(Suppl. 1): A1-227.
Setiati, S., et al. (Ed.). Buku Ajar Ilmu Penyakit Dalam Edisi Keenam Jilid III. 2014. Jakarta: Interna Publishing.
Silva, CA., Aikawa, NE. Pereira, RMR., et al. Management considerations for childhood-onset systemic lupus erythematosus patients and implications on therapy. Expert Review of Clinical Immunology. 2016; 2(3): 1-14.
Sheba, SH., Djuhaeni H., Setiabudiawan, B., Sunjaya, DK., et al.Kepatuhan Minum Obat pada Pasien Lupus Eritematosus Sistemik di RSUP Dr. Hasan Sadikin Bandung. Majalah Kedokteran Bandung. 2018; 50(1): 21-38.
Sheba, SH. Validitas dan Realibilitas Instrumen Determinan Kepatuhan Minum Obat pada Pasien Lupus Eritematosus Sistemik. Teras Kesehatan. 2018; 1(1): 25-38.
Sullivan, S. 2016. Development of a Systemic Lupus Erythematosus Knowledge Questionnaire: The Relationship Among Disease Proximity, Educational Exposure, and Knowldege. Thesis dan Disertasi. Fakultas Psikologi, University of Wisconsin Milwaukee.
Sumariyono, Kalim, H., Setyohadi, B., et al. (Ed). Rekomendasi Perhimpunan Reumatologi Indonesia Diagnosis dan Pengelolaan Lupus Eritematosus Sistemik. 2019. Jakarta: Perhimpunan Reumatologi Indonesia.
Santoso, S. 2010. Statistik Nonparametrik. Jakarta: Elex Media Komputindo.
Sugiyono. 2016. Metode Penelitian Kuantitatif Kualitatif dan R&D. Bandung: Alfabeta.
Susilani, AT. dan Wibowo, TA.Dasar-Dasar Metodologi Penelitian. 2015. Yogyakarta: Graha Cendekia.
Stalder, JF., Bernier, C., Ball, A., et al. Therapeutic patient education in atopic dermatitis: worldwide experiences. Pediatr Dermatol. 2013; 30: 329-34.
Steinkopf, L. Enhancing drug compliance and the placebo effect by raising subjective expectations. Med Hypotheses. 2012; 79: 698-700.
Storm, A., Andersen, SE., Benfeldt, E., et al.One in 3 prescriptions are never redeemed: primary nonadherence in an outpatient clinic. J Am Acad Dermatol. 2008; 59(1): 27-33.
Svendsen, MT., Andersen, F., Andersen, KH., et al. A smartphone application supporting patients with psoriasis adherence to topical treatment: a randomized controlled trial. Br J Dermatol. 2018; 179: 1062-71.
Svendsen, MT., Andersen, F., Andersen, KH., et al. Can an app supporting psoriasis patients improve adherence to topical treatment? A single-blind randomized controlled trial. BMC Dermatol. 2018; 18: 2.
Taube, KM. Patient-Doctor Relationship in Dermatology: From Compliance to Concordance. Acta Derm Venereol. 2016; Suppl 217: 25-29.
Tsokos, GC., Lo, MS. Reis, PC., et al. New Insights Into the Immunopathogenesis of Systemic Lupus Erythematosus. Nat Rev Rheumatol. 2016; 12(12): 716-30.
Utami, Safriani. 2008. Proses Penerimaan Diri Pada Wanita Penderita Systemic Lupus Erythematosus (SLE).
Vermeire, E., Hearnshaw, W., Royen, PV, et al. Patient adherence to treatment: three decades of research. A comprehensive review. Journal of Clinical Pharmacy and Terapeutics. 2001; 26: 331-42.
Vrijens, B., De Geest, S., Hughes, DA., et al. A new taxonomy for describing and defining adherence to medications. Br J Clin Pharmacol. 2012; 73: 691-705.
Wallace, DJ. dan Hahn, BH. (Ed.). 2019. Dubois’ Lupus Erythematosus and Related Syndromes Ninth Edition. Philadelphia: Elsevier.
Weinman, R. dan Horne, R. Patient Provider Interaction & Health Care Communication. Report for the National Co-ordinating Centre for NHS Service Delivery & Organization R & D (NCCSDO). Centre for Health Care Research. University of Brighton. 2005. Brighton: Falmer.
Wheelwright, S., Darlington, AS., Fitzsimmons, D., et al.International validation of the EORTC QLQ-ELD14 questionnaire for assessment of health-related quality of life elderly patients with cancer. British Journal of Cancer. 2013; 109(July): 852-8.
WHO. Adherence to Long-Term Therapies: Evidence for Action. 2003. Geneva: WHO.
Yanih, I. Kualitas Hidup Penderita Sytemic Lupus Erythematosus (SLE) Berdasarkan LupusQOL. Jurnal Berkala Epidemiologi. 2016; 4(1): 1-12.
Yen, EY. Dan Singh, RR. Brief Report: Lupus-An Unrecognized Leading Cause of Death in Young Females: A Population-Based Study Using Nationwide Death Certificates, 2000-2015. Arthritis Reumatol. 2018; 70(8): 1251-55.
Zaghloul, SS. dan Goodfield, MJ. Objective assessment of compliance with psoriasis treatment. Arch Dermatol. 2004; 140: 408-14.
Zeber, KE., Manias, E., Williams, AF., et al. A systematic literature review of psychosocial and behavioral factors associated with initial medication adherence: a report of the ISPOR medication adherence & persistence special interest group. Value in Health: The Journal of the International Society for Pharmacoeconomics and Outcome Research. 2013; 16(5): 891-900.
Zschocke, I., Ortland, C., dan Reich, K. Evaluation of adherence predictors for the treatment of moderate to severe psoriasis with biologics: the importance of physician-patient interaction and communication. J Eur Acad Dermatol Venereol. 2017; 31: 1014-20.
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